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KMID : 1009020160140030250
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Clinical Psychopharmacology and Neuroscience
2016 Volume.14 No. 3 p.250 ~ p.255
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Association of Polymorphisms within the Serotonin Receptor Genes 5-HTR1A, 5-HTR1B, 5-HTR2A and 5-HTR2C and Migraine Susceptibility in a Turkish Population
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Yavuz Yucel
Salih Co?kun
Beyhan Cengiz
Hasan H. Ozdemir
Ertu?rul Uzar
Abdullah Cim
M. Akif Camkurt
M. Ufuk Aluclu
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Abstract
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Objective : Migraine, a highly prevelant headache disorder, is regarded as a polygenic multifactorial disease. Serotonin (5-HT) and their respective receptors have been implicated in the patogenesis.
Methods : We investigated the 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptor gene polymorphisms and their association with migraine in Turkish patients. The rs6295, rs1300060, rs1228814, rs6311, rs6313, rs6314, rs6318, rs3813929 (?759C/T) and rs518147 polymorphisms were analyzed in 135 patients with migraine and 139 healthy subjects, using a BioMark 96.96 dynamic array system.
Results : We found no difference in the frequency of the analyzed eight out of nine polymorpisms between migraine and control groups. However, a significant association was found between the rs3813929 polymorphism in the promoter region of 5-HTR2C gene and migraine. Also, the allele of rs3813929 was more common in the migraine group.
Conclusion : This result suggests that the 5-HTR2C rs3813929 polymorphism can be a genetic risk factor for migraine in a Turkish population.
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KEYWORD
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Migraine disorders, Single nucleotide polymorphism, Receptor, serotonin, 5-HT2C, Genetic association studies, Headache
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